منابع مشابه
Pathogenesis of HIV-associated nephropathy.
Human immunodeficiency virus-associated nephropathy (HIVAN) is a leading cause of end-stage renal disease in the HIV-1-seropositive population. HIVAN, which is characterized by heavy proteinuria and a rapid decline in renal function, is caused by infection and subsequent expression of viral genes in renal epithelial cells, although the exact mechanism of viral entry into these cells is unknown....
متن کاملHIV Associated Lupus Like Nephropathy
BACKGROUND Human immunodeficiency virus type 1 (HIV-1)-seropositive patients are at a high risk for the development of a variety of acute and chronic renal diseases. Most patients with HIVAN are of African descent, presenting late in the course of their HIV-1 infection. The only reliable test to establish or rule out the presence of HIVAN (HIV associated nephropathy) is renal biopsy. The most c...
متن کاملRecent progress in HIV-associated nephropathy.
The classic kidney disease of HIV infection, HIV-associated nephropathy (HIVAN), is an aggressive form of collapsing focal segmental glomerulosclerosis with accompanying tubular and interstitial lesions. HIVAN was first described among African-Americans and Haitian immigrants with advanced HIV disease, an early suggestion of a strong genetic association. This genetic susceptibility was recently...
متن کاملHIV associated nephropathy: a treatable condition.
OBJECTIVES To describe current knowledge on the aetiology, pathology, diagnosis, and treatment of HIV associated nephropathy. METHODS A Medline search was performed using the key words "HIV," "nephropathy," "renal," and "kidney." A further search was performed for each of the currently licensed antiretroviral agents linked to key words "renal" or "kidney" and also using the MeSH heading "phar...
متن کاملGenetic susceptibility to HIV-associated nephropathy.
HIV-1-associated nephropathy (HIVAN) is a common complication of HIV-1 infection, and its skewed incidence in certain ethnic groups suggests that there is a genetic basis to HIVAN susceptibility. In their study reported in this issue of the JCI, Papeta and colleagues used a combination of gene expression profiling and linkage analysis to identify three genomic loci that regulate a network of ge...
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ژورنال
عنوان ژورنال: Cellular Signalling
سال: 2012
ISSN: 0898-6568
DOI: 10.1016/j.cellsig.2011.11.007